Wednesday, April 16, 2014

Toxicology Hints

Raised Anion Gap (MUDPILES)

Methanol
Uremia
DKA
Paraldehyde
INH, Iron
Lactic Acidosis
Ethanol, Ethylene glycol
Salicylates
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Whenever presented with Acidosis, Calculate the AG. After Calculating the AG, Measure Serum Osmolality and Osmolar Gap

OG = Measured Osm -  Caculated Osm

Calculated Osm = 2 Na+ + Glucose + Urea
OG more means present of other osmoles

Raised OG

Alcohols (Methanol, Ethanol, Ethylene Glycol, Isopropanol), Mannitol, Ketones
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Oral Charcoal DOES NOT help in:
(BOIL A PC)

Boric Acid
OPC
Iron
Lithium
Alcohols/Acids/Alkalies
Petroleum products
Cyanide

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GI Symptoms (Nausea, Vomiting & Diarrhoea) with Visual disturbances in an elderly is a hint towards digoxin toxicity.
Patient on digoxin & frusemide/erythromycin --- more chances of toxicity
Erythromycin/Phenothiazines prolongs QT interval and can precipitate Torsades

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